ASA may slow the spread of colon cancer

Colorectal cancer is one of the most dangerous forms of cancer, as symptoms often appear only when the disease is already quite advanced. That’s why regular checkups are especially important. A well-known and widespread pain reliever now appears to be an option as a treatment option. According to a recent study, the pain reliever ASA (acetylsalicylic acid) is able to slow down the progression of the disease.

ASA may slow the growth of colon cancer

ASA is used primarily for mild pain such as a headache, but also for fever. The active ingredient also has anti-inflammatory properties. The results of a US study now show that taking ASA prevents colon cancer cells from multiplying and makes their survival more difficult. ASA slows down the division of tumor cells as well as increases cell mortality, as reports Fitbook.de.

“Cancer occurs because cells move from a healthy state to a diseased state where they are constantly dividing. This happens when cells have acquired a series of mutations and those mutations are selected for. We found that Aspirin (a brand name of ASA) affects and slows down this formation process,” explains co-author Dominic Vodarge, a professor of public health and disease prevention at the University of California.

Mathematical models for making comprehensive predictions

With the help of a mathematical model, the scientists were able to make a comprehensive prediction at the population level considering the cell kinetics (the movement and reaction processes of cells) through the treatment with which. ace Change. “We thought that the slow growth of cancer due to ASA (aspirin) must be a result of the slow growth of cells toward malignant transformation. We were surprised that this mechanism was good enough to explain the level of protection seen in human populations. Others In words, the estimated level was consistent with the protective effect observed in epidemiological studies in human populations,” explains lead author and mathematician Natalia Komarova.

And Dominic Wodarj says: “This work is an example of how mathematical approaches can be very useful for understanding complex phenomena in cancer biology. Such insights could not have been obtained through experiments alone. requires the collaboration of empirical biological work and mathematics.”

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Sources: Fitbook.de, krebsgesellschaft.de

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