Improved recovery from nerve damage through nutrition
through intermittent fasting and the resulting change in the activity of intestinal bacteria can stimulate so-called axonal regeneration, so that Significantly improved recovery of damaged nerves,
In a recent study, experts from Imperial College London (UCL) showed that intermittent fasting was a . Promotes post-axial regeneration sciatic nerve pinch propagated in rats. The mechanism responsible for this is due to changes in the composition of intestinal bacteria.
Related study results can be found in the Journal of the English Language.Nature” for reading.
Difficulty regenerating nerve damage
The regeneration potential of neurons in the mammalian peripheral nervous system is increased after injury by them Slow axial regeneration rate severely restrictedExplain to the researchers.
Feather axon it is about nerve cell process, which are also often referred to as neuraxons. Axons transmit impulses from nerve cells to organs and form molecules known as cells.
Exercise may promote axonal regeneration
Factors Affecting Efficiency axial regeneration Injury-dependent and injury-independent mechanisms are involved. Non-injury mechanisms also include environmental factors such as: motionthat affect signaling pathways that promote axonal regeneration, the team reports.
Intermittent fasting affects important signaling pathways
According to experts it is also possible Many of these signaling pathwayschanges in gene transcription and protein synthesis, including mitochondrial metabolism and neurotrophin release, activated by intermittent fasting,
However, it is not yet clear whether intermittent fasting axial regenerative capacity influenced.
Better recovery after sciatic nerve crush
In their study, the researchers are now able to prove that intermittent fasting Favorably affects axonal regenerationAt least in rats that had suffered sciatic nerve compression.
According to the team, the effect was due to mechanisms involving the Gram-positive gut microbiome and increased serum levels of the gut bacteria-derived metabolite indole-3-propionic acid (IPA).
3-Indolepropionic acid enhances axonal regeneration
Production of 3-indolepropionic acid by clostridium sporogenes bacteria Efficient axial regeneration is essential, experts emphasize.
It has been shown that the administration of 3-indolepropionic acid after sciatica injury actually significantly improves axonal regeneration and accelerates the recovery of sensory function.
A metabolite derived from the microbiome 3-indolepropionic acid can Regeneration and functional restoration of sensory axons through a facilitating immune-mediated mechanisms,
Hope this realization will one day help to create new and efficient treatment options to develop one by one for the people nerve damage affected, conclude the researchers. (as)
Author and source information
This text matches the medical specialist literature, medical guidelines and specifications of current studies and has been checked by medical professionals.
- Elizabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, Guiping Kong, Luming Zhou, et al.: The gut metabolite indole-3 propionate promotes nerve regeneration and repair; In: Nature (published 06/22/2022), Nature
This article is general advice only and should not be used for self-diagnosis or treatment. He cannot take the place of visiting the doctor.
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